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Inhibition of gamma-glutamyl transpeptidase or cysteine S-conjugate beta-lyase activity blocks the nephrotoxicity of cisplatin in mice

It remains an investigational compound in Phase 3 clinical development

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In nature, members of the B group mostly occur together and function mainly as co-enzymes

This interaction is thought to hinder the transformation of G-actin into F-actin, a process known as actin sequestration, and is likely to increase the availability of G-actin

Gene expression analyses further indicate that GHK-Cu may affect cellular and tissue functions, extracellular matrix remodeling, redox balance, and neuronal survival