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233,234 Scientists demonstrated downregulation of histone Kla enhanced the sensitivity of CRC cells to bevacizumab treatment in cell-based xenografts, patient-derived xenografts and patient-derived organoids models, which further broadens the role of Kla in antiangiogenic therapy

Therefore, iron chelation therapy (ICT) offers a rational therapeutic option in the treatment of patients with iron overload aiming at an induction of an antileukemic effect and a reduction of secondary organ dysfunctions and infections

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After normalization of the Renilla luciferase signal to the firefly luciferase signal, miR-483-3p induced a significant decrease in the normalized luciferase activity of the vector containing the putative miRNA-binding site 2 compared with control, whereas it had no inhibitory effect on the activity of binding site 1 (Fig

The full composition is available on request for research transparency