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Guerriero, E

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At 5 and 43 days differentiation (dd), cultures were incubated with either 1 mM STS or vehicle (DMSO) for 3 h before being fixed

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Caspase-3, an important regulator of apoptotic responses, can undergo glutathionylation, leading to the inactivation of caspase-3 by GSSG in a dose- and time-dependent manner [25], suggesting that apoptosis can be regulated by glutathionylation

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However, altered thermal stability can arise either from direct Molidustat binding or from Molidustat-induced post-translational modifications affecting protein stability 42

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After four weeks, treatments can be cut down to once a week, with skin improvements anticipated in six to eight weeks

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