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Curcumin inhibited the nuclear translocation of -catenin and decresed the expression of its target genes CyclinD1, c-Myc and Axin2 in CRC cells and AOM/DSS model mice, which demonstreted Curcumin play a role in targeting the Wnt/-catenin signaling pathway ( Magnolia officinalis Rehd

In practice, this likely contributed a small amount of oxygen (from the wet paper towel), as EcN did typically form a biofilm ring at the air-liquid interface under this condition, which was absent for larger-volume biofilm cultures in culture tubes that were incubated strictly anaerobically without humidification

Then a mismatched nucleotide located at the 3 end of product RNA enters the conserved NTP entry tunnel to initiate backtracking, and meanwhile, nsp13 stimulates RdRP backtracking

Application: 1) Utilized in clinical research to study oxidative stress and cellular aging processes

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