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VIGS assays were performed as in Fig

Unlike many antioxidants that we get from food and supplements, glutathione is actually produced in the body from three precursor amino acidscysteine, glycine, and glutamine (1)

Control mice received vehicle (5% DMSO, 15% PEG400, 80% of 15% hydroxypropylgcyclodextrin (in citrate buffer pH 6.0)) injections

a secreted subtype (GPx-3)

Indeed, it was recently reported that treatment of cells with H 2 O 2 , which can lower GSH levels, leads to increased expression of NRF2 target genes in a KEAP1-independent mechanism 69

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