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The integrated application of multiomics technologies (e.g., single-cell RNA sequencing, integrated proteomics, single-cell metabolomics, and spatial omics) is critical for systematically dissecting intratumoral metabolic heterogeneity, identifying key metabolic subtypes, and revealing patterns of intercellular metabolic crosstalk to address this issue [400]

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The reason why JFH-1 is more permissive to Huh-7.5 cell lines than other genotypes is still not fully understood