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Even though edavarone seems to be of value in neurological disorders, it has limited ability to cross the BBB

These LNPs, co-encapsulating Cas9 mRNA and TatDE guide RNAs (gRNAs), can cleave the HIV genome within infected cells through tumor necrosis factor alpha (TNF-) stimulation, effectively preventing viral outgrowth (Herskovitz et al., 2021)

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doi: 10.1002/mds.25641

Besides in vitro cell culture models, organoids and simpler organisms, such as invertebrates, have been suggested to avoid classical animal testing with rodents or other mammals

Mutants that have a low ascorbate content have significant reprogramming of gene expression, including genes involved in hormone synthesis and signalling, as well as photosynthesis and defence (Kiddle et al