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In addition, production of several NF- B-mediated cytokines, including IL-6 and IL-8, has been detected in human bronchial epithelial cells in response to SARS-CoV infection (Reference Yoshikawa, Hill and Li63) , whereas patients with severe COVID-19 in intensive care units exhibit elevated plasma levels of several cytokines (IL-2, IL-7, IL-10, TNF- , MCP-1, granulocyte-colony stimulating factor (GCSF), IP-10 and macrophage inflammatory proteins (MIP1A)), suggesting a cytokine storm, resulting in hyper-inflammation (Reference Fu, Cheng and Wu64)

Inhalable dry powder formulations of resveratrol with an MMAD of 3.7 0.1 m were prepared using a spray-drying method, showing excellent lung deposition, transport and cellular uptake, which in turn inhibited the production of multiple inflammatory mediators (eg, IL-8, TNF-, and TGF-1) is expected to be efficacious in inflammatory lung diseases such as COPD

9 One Health: relevance of organosulfur compounds (OSCs) to cross-sectoral antimicrobial ecology One Health frames antimicrobial resistance (AMR) as an ecological problem spanning human, animal, and environmental health

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