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Safety and efficacy of mitapivat, an oral pyruvate kinase activator, in sickle cell disease: a phase 2, open-label study

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An attempt to identify Nrf2 target genes in cancer cells revealed that Nrf2 directly activates the genes whose products are involved in the pentose phosphate pathway and nicotinamide adenine dinucleotide phosphate (NADPH) production, such as glucose-6-phosphate dehydrogenase (G6PD), phosphogluconate dehydrogenase (PGD), transketolase (TKT) and transaldolase 1 (TALDO1), and malic enzyme 1 (ME1

Manganese exposure exacerbates progressive motor deficits and neurodegeneration in the MitoPark mouse model of Parkinsons disease: Relevance to gene and environment interactions in metal neurotoxicity

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