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Furthermore, radioresistance and damage to normal brain tissue from radiotherapy, coupled with chemotherapy limitations including poor blood-brain barrier (BBB) penetration, drug resistance, and significant side effects, collectively reduce overall treatment efficacy [7]

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doi: 10.1016/j.immuni.2016.07.008 68 ScharpingNEMenkAVMoreciRSWhetstoneRDDadeyREWatkinsSCet al

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