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Further research is needed to fully exploit potential targets

This absolute theory has been debunked because of the influence of the environment on how genes are transcribed

Fakhoury, J
NAR has been used in cosmetic, perfumery, and pharmaceutical products

Harding JL, Sooriyakumaran M, Anstey KJ, Adams R, Balkau B, Brennan-Olsen S, Briffa T, Davis TM, Davis WA, Dobson A, et al

They demonstrated that HIF-1 binds to a hypoxia response element (HRE) within the PD-L1 promoter, leading to its upregulation on both tumor cells and myeloid-derived suppressor cells (MDSCs) (157)
