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Additionally, Glutathione is essential in a broad range of metabolic processes: Glutathione acts to neutralize a toxic metabolic byproduct: Methylglyoxal

Many thiol-based ATs may lack tissue specificity, making it difficult to achieve therapeutic concentrations in the tissue/organ where the oxidative damage occurs (this phenomenon is also observed for other ATs discussed in this review)

Determination of volatile organic compounds, catechins, caffeine and theanine in Jukro tea at three growth stages by chromatographic and spectrometric methods

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Zeng et al., 2019)

Of note, Ser/Cys-94 makes contacts with a sulfate ion in the IdeS crystal structure (Wenig et al, 2004) and a partially disordered 2-mercaptoethanol molecule in the gasMac-1 crystal structure (Agniswamy et al, 2006)