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The entire c-MET I as well as the K4 and SPH domains of HGF I were absent in the reconstruction from the second class (sub-complex), which was resolved at 4 resolution (Supplementary Figs

Stress weakens these barriers, weakens the immune system in general, and exacerbates autoimmune disease
First, we further validated the role of PrP in dose-response experiments
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H 2 O 2 -induced complex formation between PDIs and GPx7/8 in cells To gain insights into physiological redox partners of GPx7 and GPx8, we next transfected HeLa cells with plasmids expressing FLAG-tagged Prx4, GPx7, or full-length GPx8, treated the cells with or without 5 mM H 2 O 2 for 10 min, and alkylated the free cysteines with N -maleimide (NEM) as described in Experimental Procedures, followed by immunoprecipitation and immunoblotting with an antibody against each PDI family member (Fig

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