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10.1001/archinte.164.20.2206 14 AridgidesD

Research Priorities Priority studies should include rigorous human PK (multiple routes, dose proportionality), double blind placebo controlled dose ranging Phase II trials for a single indication (e.g

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Abbreviations AAA: Aromatic Amino Acids ACC: Acetyl-Coa Carboxylase AD: Alzheimers Disease ALP: Alkaline Phosphatase ALS: Amyotrophic Lateral Sclerosis ALT: Alanine Aminotransferase ANGPTL3: Angiopoietin-Like Protein 3 ApoA-I: Apolipoprotein A-I ApoB: Apolipoprotein B ApoE: Apolipoprotein E ApoJ: Apolipoprotein J AREs: Antioxidant Response Elements ASO: Antisense Oligonucleotide AST: Aspartate Transaminase ATF2: Activating Transcription Factor 2 ATF4: Activating Transcription Factor 4 ATF5: Activating Transcription Factor 5 ATF6: Activating Transcription Factor 6 -syn: -synuclein A: -amyloid BAT: Brown Adipose Tissue BBB: Blood-Brain Barrier BCAAs: Branched-Chain Amino Acids BDNF: Brain-Derived Neurotrophic Factor BMI: Body Mass Index CET: Continuous Exercise Training ChREBP: Carbohydrate Response Element-Binding Protein CNS: Central Nervous System CSF: Cerebrospinal Fluid CEC: Cholesterol Efflux Capacity ER: Endoplasmic Reticulum EDSS: Expanded Disability Status Scale FAP: Fibroblast Activation Protein FCS: Fluorescence Correlation Spectroscopy FFAR4: Free Fatty Acid Receptor 4 FGF: Fibroblast Growth Factor fMRI: Functional Magnetic Resonance Imaging FST: Follistatin GGT: Gamma-Glutamyl Transferase GRP78: Glucose-Regulated Protein 78 Gpx3: Glutathione Peroxidase 3 Gpx4: Glutathione Peroxidase 4 GWAS: Genome-Wide Association Studies HDL: High-Density Lipoprotein HIIT: High-Intensity Interval Training HMGB1: High-Mobility Group Box 1 Hnf4: Hepatic Nuclear Factor 4 Alpha HSA: Human Serum Albumin IR: Insulin Resistance LDL: Low-Density Lipoprotein LDL-C: Low-Density Lipoprotein Cholesterol LPL: Lipoprotein Lipase LRP-1: LDL Receptor-Related Protein 1 MANF: Midbrain Astrocyte-Derived Neurotrophic Factor MASLD: Metabolic-Associated Fatty Liver Disease MCI: Mild Cognitive Impairment MMSE: Mini-Mental State Examination MoCA: Montreal Cognitive Assessment MS: Multiple Sclerosis NAFLD: Nonalcoholic Fatty Liver Disease NF-B: Nuclear Factor -Light-Chain-Enhancer of Activated B Cells NSC: Neural Stem Cell PD: Parkinsons Disease PDHC: Pyruvate Dehydrogenase Complex PET: positron emission computed tomography PUFAs: Polyunsaturated Fatty Acids rFGF-21: Recombinant FGF-21 ROS: Reactive Oxygen Species Se: Selenium Sec: Selenocysteine SELENOP: Seleno-protein P SelP-H: histidine-rich domain of SELENOP SHBG: Sex Hormone-Binding Globulin SMOC1: Sparc-Related Modular Calcium-Binding Protein 1 sEH: Soluble Epoxide Hydrolase TG: Triglyceride TSK: Tsukushi T2DM: Type 2 Diabetes Mellitus UPR: Unfolded Protein Response VLDL: Very Low-Density Lipoprotein References Nedelec T, Couvy-Duchesne B, Monnet F, Daly T, Ansart M, Gantzer L, Lekens B, Epelbaum S, Dufouil C, Durrleman S