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In rare cases, patients also have low levels of ketones, which might therefore be misinterpreted as respiratory-chain defects [27]

Importantly, autoradiographic analyses in the basal ganglia and cortex of RS patients showed reduced density of -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), N-methyl-D-aspartate (NMDA), and GABA receptors [375]

Although not directly investigated in SCI models, these mitochondrial regulatory mechanisms may provide mechanistic insights relevant to post-injury metabolic dysregulation (104, 105)

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