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OhkamaOhtsu et al

In addition, double knockouts of PGC-1 and PGC-1 in skeletal muscle or the adult heart did not result in a loss in mitochondrial mass, which indicated that PRC may play a role in mitobiogenesis in the absence of PGC-1 and PGC-1 [71, 72], a finding that warrants further investigation

It does so by activating genes that are associated with repair and regeneration while suppressing those linked to inflammation and aging

Funding This research was supported by Conselho Nacional de Desenvolvimento Cientfico e Tecnolgico (CNPq), Coordenao de Aperfeioamento de Pessoal de Nvel Superior (CAPES), Fundao de Amparo Pesquisa do Estado do Rio Grande do Sul (FAPERGS) and Instituto Nacional de Cincia e Tecnologia para Excitotoxicidade e Neuroproteo

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These brain cells, containing high level of iron, have a major susceptibility to ferroptosis and exacerbate neuronal death