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The combination of these two regulating approaches can together form an antioxidant system independent of Cysteine/GSH/GPX4 axis ( Role of Tumour Suppressor Genes in Ferroptosis Previous investigation have reported that two tumour suppressor genes [p53 and BRCA1-associated protein 1 (BAP1)] played significant roles in regulating tumour by targeting ferroptosis

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and eicosanoids (e.g., prostaglandins and leukotrienes) that are derived from arachidonic acid

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