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[DOI] [PubMed] [Google Scholar] 67.Motzer RJ, Rini BI, Bukowski RM, et al

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What NOT to expect in the first 3 nights: Sedation (DSIP is not a sedative a drugged or groggy feeling is a signal to check the dose) Complete resolution of chronic insomnia (sleep architecture remodeling takes longer) Stress or cortisol changes (HPA axis modulation requires sustained dosing) Administration timing: Community protocols describe subcutaneous DSIP 30-60 minutes before the intended sleep time