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Its important to note that while these vitamins are essential for maintaining good health, taking excessive amounts of Vitamin B6 and B12 can lead to adverse side effects

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Beyond vascular [79,80] and immune functions [81,82,83], NO contributes to central and peripheral sensitization by modulating excitatory neurotransmission and interacting with cyclic GMP pathways [84,85,86]

Subsequently many other mutations were found to be associated with familial forms of PD (Flagmeier et al., 2016) including the A30P mutant aggravating PD by reduced autophagic clearance of protein aggregates (Lei et al., 2019) and E46K mutant which promotes fibrillation of N acetylated -synuclein by abolishing the long-range electrostatic interactions (Zhao et al., 2020)

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