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The composition of the vesicle is a crucial element that directly affects the physical and chemical characteristics of the ethosome, affecting a number of aspects, including the bilayers flexibility, size, charges, and thermodynamic state

[DOI] [PubMed] [Google Scholar] 125.Mrtensson J., Lai J.C., Meister A

With little CYP interaction, PHL should be pharmacokinetically stable and less subjected to metabolic variability

Clin Exp Pharma Physio 35:11161120

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(ii) The metabolic degradation of both vitamins starts with an initial -hydroxylation by CYP4F2