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Neuropathology hallmarks of AD such as amyloid beta (A) plaques and neurofibrillary tangles containing the neuron-specific protein tau is associated with changes in fluid biomarkers including A, phosphorylated tau (p-tau)-181, p-tau 231, p-tau 217, glial fibrillary acidic protein (GFAP), and neurofilament light (NFL)

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