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Unoki et al (161) demonstrated that AGE-RAGE interaction increased intracellular oxidative stress, causing a decrease in glucose uptake in cultured 3T3-L1 adipocytes

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The Pax7 transcription factor has been shown to be a key determinant of melanotroph identity, and it works by remodeling chromatin prior to Tpit expression, opening key areas of chromatin to allow Tpit and other transcription factors access to enhancers, resulting in melanotroph specification (13)

10.1016/j.pharmthera.2021.108053 104 UnterbergerS.DaviesK

Dosage and Administration: Give 5 - 10mL by intramuscular injection regularly twice weekly or as advised by a veterinary surgeon