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Fowler, pp

These data show that the loss of fatty acid catabolism at different points results in unique cellular and physiological effects

In a nutshell, ROS generation, lipid peroxidation, accumulation of H 2 O 2 in tumor microenvironment, 1 O 2 and O 2 generation, conversion of Fe 3+ to Fe 2+ during Fenton reaction are major responsible factors in ferroptosis-mediated therapy

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Strikingly different clinicopathological phenotypes determined by progranulin-mutation dosage