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PDIp accepts electrons from the nascent polypeptide chain, resulting in oxidation of the active site cysteines

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Immunol 187:418798 [DOI] [PMC free article] [PubMed] [Google Scholar] 57.Mayer A, Denanglaire S, Viollet B, Leo O, Andris F

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In the liver, a particular metabolic pathway called transsulfuration permits the supply of cysteine by conversion of an essential amino acid: methionine
