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Avoid concomitant administration of ibuprofen for 2 days before, the day of, and 2 days following administration of Pemetrexed Injection [see Warnings and Precautions (5.6) and Drug Interactions (7)]

Blood samples from healthy individuals were collected and analyzed and routine clinical plasma B12 and methylmalonic acid results extracted to establish reference intervals

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Studies suggest that up to 30% of patients hospitalized for depression are deficient in B12, and that B12 concentrations in blood are generally lower in depressed patients than nondepressed patients

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