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This triggers a process in which phagocytes elevate their oxygen consumption [3, 4]

Citation: Wilding, J

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PMID: 21057789

During the G0 phase, ROS activate the NRF2 and p53 signaling pathways 79 , induce CDKN1A (p21) expression 80 , inhibit CDK4/6 and Cyclin D1 activity, and maintain G0 phase arrest via the involvement of p27 and p38 80,81,82,83 In the G1 phase, ROS activate the PI3K/AKT 84,85 and SIRT1/FOXO3 signaling pathways 86,87,88 , thereby inducing the expression of p27, p53, and p16INK4A 86 , suppressing CDK4/6 and Cyclin D activity 89 , and preventing cell entry into the S phase