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doi: 10.1001/jama.1926.02680070016005 32

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Exogenous administration of synthetic Ec peptides leads to phosphorylation of extracellular signal regulated kinases (ERK1 and ERK2), serine/threonine-specific protein kinase (Akt), IGF-1 and insulin receptor-independent cell growth [16] and produces mitogenic effect on human cell lines [17,18]

TEM imaging confirmed the uniform morphology of the nanoparticles that are spherical, while DLS analysis showed a particle size of 248.53 16.25 nm with a PDI of 0.274 and a zeta potential of 2.63 0.74 mV, confirming the colloidal stability

The D-Nle-Trp-Ile-NH-(CH 2 )5- CONH 2 analog had intermediate inhibitory activity, and the D-Nle-Met-Ile-NH-(CH 2 )5- CONH 2 analog showed no ability to effect on Met activation