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(2023) 42:e111620

Cysteine catabolism and the serine biosynthesis pathway support pyruvate production during pyruvate kinase knockdown in pancreatic cancer cells

Abbreviations AEG-1: Astrocyte Elevated Gene-1 AMPA: -Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid CNQX: Cyanquixaline CNS: Central Nervous System D-AP5: D(-)-2-Amino-5-Phosphonopentanoic Acid EAAT: Excitatory Amino Acid Transporter FAK: Focal Adhesion Kinase FDA: Food and Drug Administration GA: Glutaminase GLAST: Glutamate/Aspartate-Transporter Gln: Glutamine GLT1: Glutamate Transporter 1 Glu: Glutamate GS: Glutamine Synthase GSCs: Glioma Stem Cells GSH: -L-Glutamyl-L-Cysteinylglycine IDH: Isocitrate Dehydrogenase iGluR: Ionotropic Glutamate Receptors MAPK: Mitogen-Activated Kinase mGluR: Metabotropic Glutamate Receptors NBQX: 2,3-Dihydroxy-6-Nitro-7-Sulfamyl-Benz(f)Quinoxaline NMDA: N-Methyl-D-Aspartate PI3K: Phosphatidylinositol-3-Kinase PPAR: Peroxisome Proliferator Activated Receptor Gamma ROS: Reactive Oxygen Species S-4CPG: (S)-4-Carboxyphenylglycine SAS: Sulfasalazine SNAT: Sodium-Coupled Neutral Amino Acid Transporter Sxc: System x c - TME: Tumor Microenvironment TMZ: Temozolomide References Ostrom QT, Price M, Neff C, Cioffi G, Waite KA, Kruchko C, et al

Both specific target cells and non-specific target cells can endocytose positively charged particles by electrostatic interactions in vitro to achieve high performance in gene delivery