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Funding This work was supported by National Natural Science Foundation of China (81872603 and 81872575), Natural Science Foundation of Shandong Province (ZR2019MH102), Science and Technology Plan of Jinan City (201907061), the Innovation Project of Shandong Academy of Medical Sciences, Academic Promotion Programme of Shandong First Medical University (2019QL001 and 2019QL003), the Central Government Guides Local Science and Technology Development Project of Shandong Province (YDZX20203700002055), and the Major Science and Technology Innovation Project of Shandong Province (2021SFGC0502)

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doi: 10.5402/2011/260537