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Transcription of ARE results in the production of numerous antioxidant enzymes, such as SOD, GPx, glutathione-s-transferase(GSTr), catalase (CAT), heme-oxygenase-1 (HO-1), NADPH-quinone-oxidoreductase (NQO-1), phase II enzymes of drug metabolism and heat shock proteins (HSP)

By targeting distinct but interconnected pathways, this synergy could more effectively counteract the oxidative stress and inflammatory cascades that fuel colorectal tumorigenesis

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