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Spermidine is a polyamine whose concentration can reach the millimolar range in the intracellular environment, while extracellularly it is present in the low micromolar range (Heller et al., 1978

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Additionally, GLUT1 mRNA expression is upregulated by Src or Ras protein, mostly in the presence of two enhancer elements in the gene [10]

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This offers new perspectives for treatment not only in melanoma but also in other tumors

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