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This is consistent with the methyl folate trap hypothesis (54), which predicts that, in vitamin B-12 deficiency, the inhibition of DNA synthesis and cell proliferation is removed upon administration of high doses of folic acid because of increased availability of nonmethylated folate

But as your B12 level rises, you wont need them more frequently

Radioimmunoassay of growth hormone-dependent insulin-like growth factor binding protein in human plasma

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