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Lipolysis can be locally sensed in white fat by afferent nerves to trigger a neural circuit from WAT to BAT that acutely induces BAT thermogenesis, mediated by representative FAs eicosopentanoic acid and arachidonic acid (154)

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Bi-Amino Injection should therefore be considered only when potential maternal-fetal benefits clearly outweigh theoretical risks, and treatment should proceed in high-risk obstetric units where serial fetal surveillance and maternal laboratory assessment are feasible