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doi: 10.1016/j.cell.2011.02.013 7 WishartDS

But over months and years of treatment, even weekly injections in the same spot accumulate

This initiation dose establishes baseline receptor activation

Cirrhosis damage is generally permanent, but you can stop it from progressing with early treatment for the underlying condition

Think of a wilted plant getting watered - same concept, but with your face

For these localized applications, systemic absorption may matter less than direct contact with digestive tissues
