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Inter-animal variability, calculated as the coefficient of variation (%CV) based on the summed intensities of all detected ions across analysed regions, was 5.28% in negative ion mode and 5.57% in positive ion mode

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Together, aberrant DNA methylation, dysregulated histone post-translational modifications, and altered non-coding RNA expression converge to disrupt normal cardiovascular physiology as well as the cardiac transcriptional landscape, driving maladaptive gene expression that promotes fibrosis, inflammation, and apoptosis in diabetic heart disease

Compounds were injected for 150 s, and the corresponding dissociation constants were measured for 300 s

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