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In fish, amphibians, reptiles, and bird species belonging to older taxonomic orders the enzymes involved in vitamin C biosynthesis are located mainly in the kidneys, while in mammals and bird species from more recent orders these enzymes are found mainly in the liver (Grollman and Lehninger, 1957

All cell culture products were purchased from Thermofisher (Waltham, MA)

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Hatzichristodoulou G, Osmonov D, Kubler H, Hellstrom WJG, Yafi FA