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Depigmentation of SNpc results from the absence of these neurons, which normally contain modest levels of melanin (Lees, 2012)

Buccellato FR, DAnca M, Fenoglio C, Scarpini E, Galimberti D

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97 demonstrated that hypoalbuminemia which is often associated with malnutrition, contributed to subnormal ALP levels

This indicates that reduction of MGO and MGO-derived AGEs in microglia reduces the microglial pro-inflammatory state in vivo
