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(1974) Epidemiological studies on renal failure of inhabitants in Itai-Itai disease endemic district

A B12 deficiency can lead to signs such as fatigue and lowered appetite, and as many as 16% of U.S

doi: 10.1016/j.amjmed.2003.08.027

Because SDH is the only enzyme that participates in both the TCA cycle and the ETC, we speculated that the ETC might be compromised in Gclc -deficient FoB, thus explaining the inhibition of SDH and the accumulation of succinate

This suggests that precise dosing may be less critical than consistent daily administration over an adequate duration

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