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The CVMA brings forth concerns today in the Board of Pharmacy sunset review over veterinary drug availability in California

These off-target effects complicate the interpretation of research results that use these compounds as selective GHS-R probes, and have driven decades of medicinal chemistry effort to develop a cleaner alternative

[DOI] [PubMed] [Google Scholar] Rocca A., Minucci S., Tosti G., Croci D., Contegno F., Ballarini M., Nol F., Munzone E., Salmaggi A., Goldhirsch A

10.1126/science.aas8836

doi: 10.1074/jbc.M115.703066

Furthermore, niacin binds to the G-protein-coupled hydroxycarboxylic acid receptor 2, which is upregulated in a proinflammatory environment and which may downregulate inflammation (164166)