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To ensure reliable generalization estimates, we performed stratified fivefold cross-validation on an 80:20 train:test split, maintaining the positive:negative ratio within each fold

Transcriptome profiling study identified differentially expressed miRNAs in four major life stages of and validated them by using real-time PCR experiments [235]

The light energy from IPL is absorbed by melanin, which gradually breaks down the pigment, resulting in an overall brighter and more even complexion

Isolation of human glucose-6-phosphate dehydrogenase (G6PD) cDNA clones: primary structure of the protein and unusual 5 non-coding region

As the sole intracellular LPO-reducing enzyme, the lack of GPX4 results in excessive accumulation of LPO, destabilizing biological membranes, exacerbating oxidative stress, and ultimately promoting ferroptosis (Ursini and Maiorino, 2020)

Regarding the modulation of the expression of MMPs, proteins that promote the remodeling of the extracellular matrix (ECM) [59] , melatonin achieves this repressive effect by inhibiting the p38 MAPK signaling pathway through PKA, exerting a negative effect on transcription by NF-kB, and even by docking directly at the MMP-9 activation site [28,62]