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M.SuY.Hari-RajA.DincerA.FloresS.et al

ANIMAL EXPERIMENTS ESSENTIAL FOR THE UNDERSTANDING OF HUMAN INSULIN-GH-IGF AXIS PHYSIOLOGY Insulin, IGF-I, and IGF-II and Their Receptors Efstratiadis series of knock-outs of the insulin-GH-IGF-axis in mice in the early 1990s clearly confirmed its importance in fetal and postnatal growth and metabolism (21)

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We retested these compounds in IMR90 ER:RAS cells, and in a melanoma cell line, SK-MEL-103, in which we induced senescence by treatment with the chemotherapeutic agent etoposide or the Aurora kinase inhibitor tozasertib (Supplementary Fig

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176 When compared to insulin, insulin-like growth factor 1 (IGF1) showed relative lower binding affinity to insulin receptors