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Astrocytes: key regulators of neuroinflammation

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Li J, Xu J, Yan X, Jin K, Li W, Zhang R

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182,183 Moreover, physcion and its derivative S3, novel small-molecule PGD inhibitors which fits in a pocket of PGD near the binding site of 6-PG to inhibit PGD enzyme activity and then decrease the NADPH level, exhibit excellent anticancer effects and sensitize leukemia cells to antimalarial agent dihydroartemisinin (DHA)

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