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Description
Vitamin B12 Deficiency, folate deficiency, and methyl trapping People with MTHFR gene mutations often have hidden B12 deficiencies which cause the active form of folate 5-methyl THF or 5-methyltetrahydrofolate to become trapped, this is known as the methyl-folate trap, when this happens, taking the MTHFR recommended supplements can cause serious harm and should be avoided until the underlying reasons for the B12 deficiency can be addressed and the right type of B12 can be prescribed

doi: 10.1016/j.chom.2013.07.007 60 JansCBoleijA

Chubb, B., Gupta, P., Gupta, J

And a question that has stopped thousands of researchers in their tracks

B12 is often weekly to monthly for deficient patients, tapering as levels normalize

None of this is complicated once someone walks through it clearly
