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When dieting, a B12 deficiency can occur due to the limitation of consumption of foods that are high in B12, such as red meat

Vaquer-Alicea and Diamond 2019)
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TB-500 ~5 mg/week (2.5 mg, 2/wk)

To put this simply, it wears off - it does not last

It also appears to reduce VEGF (vascular endothelial growth factor) expression (Li 2013), increase expression of the tumor suppressor protein p53, and inhibit COX-2 expression (Lu 2012)
