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After ligand binding, the activated IGF-1 or insulin receptor phosphorylates several intracellular substrates, including IR substrates (IRS) and the Src-homology-2-domain containing transforming protein (Shc)

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In addition, clinical data also suggest L-carnosine exhibited a neuroprotective activity against OIPN in CRC patients by targeting Nrf-2 and NF-B pathways (Yehia et al., 2019)