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Meanwhile, HIF1 stimulates glycolysis to sustain cell proliferation [76]

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The TgAPParc mouse model, which carries the E693G mutation (APP695) under the control of the murine Thy1.2 promoter, exhibited 3- to 7-fold higher mutant human APP expression compared to endogenous mouse APP

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Another role of PKC is to mediate the stimulation of proinflammatory cyclooxygenase-2 expression by viral spike protein through both calcium-dependent (PKC) and calcium-independent mechanisms (PKC, NF-B, ERK, PI3K) (282)