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The primary preclinical evidence comes from mouse studies showing reduced body weight and adipose mass in diet-induced obese mice (2018), improved grip strength in aged mice (2024), and beneficial microbiome changes when combined with caloric restriction (2022)

[DOI] [PubMed] [Google Scholar] 11.Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM

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