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While ample studies exist describing BBB dysfunction in animal models of epilepsy, there is little understanding of the underlying molecular drivers of BBB disruption, which means that targeted regulation of BBB dysfunction is a tantalising but unexplored therapeutic channel for novel epilepsy treatment

Due to epitope heterogeneity, there may be a chance that prior exposure to SARS-CoV-2 or other coronaviruses may trigger ADE 129,130

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Interestingly, we also found that the hypoxia-induced decline in PP2A activity was reversed when -syn or p--syn was interfered with, suggesting that hypoxia-induced PP2A inhibition and -syn pathology are mutually reinforcing vicious cycles

doi: 10.1016/j.addr.2011.06.016