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A study where healthy individuals received a -HB infusion to achieve a concentration of approximately 5.5 mmol/L demonstrated a 14% reduction in brain glucose utilization and a significant 30% increase in cerebral blood flow, with unchanged oxygen consumption [77]
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Microglia-mediated neuroinflammation: a potential target for the treatment of cardiovascular diseases
The subsequent production of inflammatory cytokines, such as IL-1, IL-6, and TNF-, by these nociceptive free endings elicit spontaneous, repetitive action potentials in sensory afferents
