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48 Furthermore, BCAAs are essential for the proper function of immune cells in the immune system, promoting lymphocyte proliferation and cytotoxic T-cell activation through the oxidative decomposition of dehydrogenase and decarboxylase expressed by immune cells

Exogenous IGF-1 appears to activate them before they would naturally be activated

One modification is methylation catalyzed by histone methyltransferase enzymes that add methyl groups to specific residues on different histones